货号：E-2024065912
CAS：327036-89-5
规格：mg(更多包装需求请咨询客服)
纯度：95%+
生产商：试剂家

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Catalogue Number:B285725
Chemical Name:4-Benzyl-2-methyl-1,2,4-thiadiazolidine-3,5-dione
Synonyms:GSK-3ß Inhibitor I, TDZD-8
CAS Number:327036-89-5
Molecular Formula:C₁₀H₁₀N₂O₂S
Appearance:White Solid
Melting Point:60-61°C
Molecular Weight:222.26
Storage:-20°C
Solubility:Hexane
Category:Research Tools; Enzyme Activators and Inhibitors;
Applications:Glycogen Synthase Kinase-3ß is a highly conserved ubiquitously expressed serine/threonine protein kinase involved in signal transduction cascades of multiple cellular processes. TDZD-8 is a thiadiazolidinone (TDZD) analogue that acts as a highly selective, non-ATP competitive inhibitor of GSK-3ß ( IC50 =2nM). Binds to the active site of GSK-3ß. Does not significantly affect the activities of Cdk-1/cyclin B, CK-II, PKA, and PKC (IC50 >100nM).
References:Martinez, A., et al.: J. Med. Chem., 45, 1292 (2002)
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