货号：E-2024066462
CAS：142799-22-2
规格：mg(更多包装需求请咨询客服)
纯度：95%+
生产商：试剂家

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Catalogue Number:B347130
Chemical Name:1,3-Bis(3-chloropropyl)-1,3-dihydro-2H-benzimidazol-2-one (~90%)
CAS Number:142799-22-2
Molecular Formula:C₁₃H₁₆Cl₂N₂O
Appearance:White to Off-White Solid
Melting Point:66°C
Molecular Weight:287.18
Storage:-20°C
Solubility:Chloroform (Slightly), Water (Slightly, Heated, Sonicated)
Category:Building Blocks; Miscellaneous;
Applications:1,3-Bis(3-chloropropyl)-1,3-dihydro-2H-benzimidazol-2-one (~90%) is an intermediate in the synthesis of 3’-[4-(5-Chloro-2,3-dihydro-2-oxo-1H-benzimidazol-1-yl)-1-piperidinyl]propyl Domperidine (Domperidine Impurity F) (C365315), an impurity of the gastrokinetic and antinauseant drug Domperidone (D531100(P)), which is a novel peripheral dopamine receptor antagonist that does not cross the blood-brain barrier; anti-emetic. Domperidone(Motilium) is a dopamine blocker and an antidopaminergic reagent.
References:Baudry, M., et al.: Arch. Pharmacol., 308, 231 (1979), Ennis, C., et al.: J. Pharm. Pharmacol., 31, 14 (1979), Brogden, R.N., Drugs, 24, 360 (1982),
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